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In 2017, French researchers from the Institut National de la Recherche Agronomique (INRAE) were among the first to examine the effects of E171 nanoparticles on the body. They fed rats a dose of 10mg of E171 per kilogram of body weight per day, which was similar to human exposure in food. The research, which was published in Scientific Reports, showed that E171 was able to traverse the intestinal barrier, pass into the bloodstream, and reach other areas of the body in rats. Researchers also found a link between immune system disorders and the absorption of titanium dioxide nanoparticles. 

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The factory's production process is a testament to precision and optimization. Raw materials, primarily ilmenite, rutile, and anatase ores, undergo a rigorous refining process that includes crushing, leaching, and solvent extraction methods. These steps ensure the purity and consistency required for high-quality pigments. Following this, gaseous chlorination converts the refined ore into titanium tetrachloride, setting the stage for the final synthesis of titanium dioxide through the oxidation of titanium tetrachloride in a heated environment.

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